WEN Laboratory

Selected Publications

2024 (1)

Nguyen, T. M. L., Hassan, S., Pan, H., Wu, S., & Wen, Z. (2024). Interplay of Zeb2a, Id2a, and Batf3 regulates microglia and dendritic cell development in the zebrafish brain. Development (Cambridge, England), dev.201829. Advance online publication. https://doi.org/10.1242/dev.201829

2023 (4)

Zhang, A.#, Lu, J.#, Feng, S., Yu, H., Yu, T., Zhao, S., Chen, K., Huang, Z., Xu, J., Qu, J. Y., & Wen, Z. (2023). Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish. Journal of genetics and genomics, S1673-8527(23)00237-0. Advance online publication. https://doi.org/10.1016/j.jgg.2023.11.001 (# equal contribution)

Yu, T.#, Kuang, H.#, Wu, X., Huang, Y., Wang, J., & Wen, Z. (2023). Cell competition for neuron-derived trophic factor controls the turnover and lifespan of microglia. Science advances, 9(24), eadf9790. https://doi.org/10.1126/sciadv.adf9790(# equal contribution )

Zhou, Q.#, Zhao, C.#, Yang, Z., Qu, R., Li, Y., Fan, Y., Tang, J., Xie, T., & Wen, Z. (2023). Cross-organ single-cell transcriptome profiling reveals macrophage and dendritic cell heterogeneity in zebrafish. Cell reports, 42(7), 112793. https://doi.org/10.1016/j.celrep.2023.112793(# equal contribution)

Zhao, C., Li, Y., Tang, J., Zhou, Q., Lin, X., & Wen, Z. (2023). Metaphocytes are IL-22BP-producing cells regulated by ETS transcription factor Spic and essential for zebrafish barrier immunity. Cell reports, 42(5), 112483. https://doi.org/10.1016/j.celrep.2023.112483

2022 (4)

Zhao, S.#, Zhang, A.#, Zhu, H., & Wen, Z. (2022). The ETS transcription factor Spi2 regulates hematopoietic cell development in zebrafish. Development (Cambridge, England), 149(19), dev200881. https://doi.org/10.1242/dev.200881 (# equal contribution)

Dai, Y.#, Wu, S.#, Cao, C., Xue, R., Luo, X., Wen, Z.*, & Xu, J.* (2022). Csf1rb regulates definitive hematopoiesis in zebrafish. Development (Cambridge, England), 149(16), dev200534. https://doi.org/10.1242/dev.200534 (# equal contribution; * co-corresponding author)

Lou, L.#, Yu, T.#, Dai, Y., Zhao, S., Feng, S., Xu, J., & Wen, Z. (2022). Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression. Proceedings of the National Academy of Sciences of the United States of America, 119(39), e2203273119. https://doi.org/10.1073/pnas.2203273119 (# equal contribution)

Zhao, S.#, Feng, S.#, Tian, Y.#, & Wen, Z. (2022). Hemogenic and aortic endothelium arise from a common hemogenic angioblast precursor and are specified by the Etv2 dosage. Proceedings of the National Academy of Sciences of the United States of America, 119(13), e2119051119. https://doi.org/10.1073/pnas.2119051119 (# equal contribution)

2021 (3)

Li, H., Nam, Y., Huo, R., Fu, W., Jiang, B., Zhou, Q., Song, D., Yang, Y., Jiao, Y., Weng, J., Yan, Z., Di, L., Li, J., Wang, J., Xu, H., Wang, S., Zhao, J., Wen, Z., Wang, J., & Cao, Y. (2021). De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation. Circulation research, 129(9), 825–839. https://doi.org/10.1161/CIRCRESAHA.121.319004

Zhao, Y., Wu, M., Li, J., Meng, P., Chen, J., Huang, Z., Xu, J., Wen, Z., Zhang, W., & Zhang, Y. (2021). The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway. Cell death & disease, 12(10), 906. https://doi.org/10.1038/s41419-021-04215-4

Chen, J., Li, G., Lian, J., Ma, N., Huang, Z., Li, J., Wen, Z., Zhang, W., & Zhang, Y. (2021). Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. Science China. Life sciences, 64(12), 2186–2201. https://doi.org/10.1007/s11427-020-1878-8

2020 (5)

Wu, S.#, Nguyen, L. T. M.#, Pan, H., Hassan, S., Dai, Y., Xu, J., & Wen, Z. (2020). Two phenotypically and functionally distinct microglial populations in adult zebrafish. Science advances, 6(47), eabd1160. https://doi.org/10.1126/sciadv.abd1160 (# equal contribution)

Lin, X.#, Zhou, Q.#, Lin, G., Zhao, C., & Wen, Z. (2020). Endoderm-Derived Myeloid-like Metaphocytes in Zebrafish Gill Mediate Soluble Antigen-Induced Immunity. Cell reports, 33(1), 108227. https://doi.org/10.1016/j.celrep.2020.108227 (# equal contribution)

Yu, T., Kuang, H., Chen, J., Lin, X., Wu, Y., Chen, K., Zhang, M., Zhang, W.*, & Wen, Z.* (2020). Tripartite-motif family protein 35-28 regulates microglia development by preventing necrotic death of microglial precursors in zebrafish. The Journal of biological chemistry, 295(26), 8846–8856. https://doi.org/10.1074/jbc.RA119.012043 (* co-corresponding author)

He, S., Xu, J., Qu, J. Y.*, & Wen, Z.* (2020). Lightening the way of hematopoiesis: Infrared laser-mediated lineage tracing with high spatial-temporal resolution. Experimental hematology, 85, 3–7. https://doi.org/10.1016/j.exphem.2020.04.009 (invited review; * corresponding author)

He, S.#, Tian, Y.#, Feng, S.#, Wu, Y., Shen, X., Chen, K., He, Y., Sun, Q., Li, X., Xu, J., Wen, Z.*, & Qu, J. Y.* (2020). In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy. eLife, 9, e52024. https://doi.org/10.7554/eLife.52024

2019 (3)

Wang, T.#, Yan, B.#, Lou, L., Lin, X., Yu, T., Wu, S., Lu, Q., Liu, W., Huang, Z., Zhang, M., Zhang, W.*, & Wen, Z.* (2019). Nlrc3-like is required for microglia maintenance in zebrafish. Journal of genetics and genomics = Yi chuan xue bao, 46(6), 291–299. https://doi.org/10.1016/j.jgg.2019.06.002

Lin, X., Zhou, Q., Zhao, C., Lin, G., Xu, J., & Wen, Z. (2019). An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis. Developmental cell, 49(4), 605–617.e5. https://doi.org/10.1016/j.devcel.2019.03.028

Jin, W.#, Dai, Y.#, Li, F., Zhu, L., Huang, Z., Liu, W., Li, J., Zhang, M., Du, J., Zhang, W.*, & Wen, Z.* (2019). Dysregulation of Microglial Function Contributes to Neuronal Impairment in Mcoln1a-Deficient Zebrafish. iScience, 13, 391–401. https://doi.org/10.1016/j.isci.2019.02.031

2018 (2)

Wu, S., Xue, R., Hassan, S., Nguyen, T. M. L., Wang, T., Pan, H., Xu, J., Liu, Q., Zhang, W., & Wen, Z. (2018). Il34-Csf1r Pathway Regulates the Migration and Colonization of Microglial Precursors. Developmental cell, 46(5), 552–563.e4. https://doi.org/10.1016/j.devcel.2018.08.005

He, S., Chen, J., Jiang, Y., Wu, Y., Zhu, L., Jin, W., Zhao, C., Yu, T., Wang, T., Wu, S., Lin, X., Qu, J. Y., Wen, Z., Zhang, W.*, & Xu, J.* (2018). Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells. eLife, 7, e36131. https://doi.org/10.7554/eLife.36131

2017 (3)

Tian, Y., Xu, J., Feng, S., He, S., Zhao, S., Zhu, L., Jin, W., Dai, Y., Luo, L., Qu, J. Y., & Wen, Z. (2017). The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells. The Journal of experimental medicine, 214(11), 3347–3360. https://doi.org/10.1084/jem.20170488

Yu, T., Guo, W., Tian, Y., Xu, J., Chen, J., Li, L., & Wen, Z. (2017). Distinct regulatory networks control the development of macrophages of different origins in zebrafish. Blood, 129(4), 509–519. https://doi.org/10.1182/blood-2016-07-727651

Liu, W., Wu, M., Huang, Z., Lian, J., Chen, J., Wang, T., Leung, A. Y., Liao, Y., Zhang, Z., Liu, Q., Yen, K., Lin, S., Zon, L. I., Wen, Z., Zhang, Y., & Zhang, W. (2017). c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish. Leukemia, 31(1), 222–233. https://doi.org/10.1038/leu.2016.170

2016 (4)

Dai, Y., Zhu, L., Huang, Z., Zhou, M., Jin, W., Liu, W., Xu, M., Yu, T., Zhang, Y., Wen, Z., Liao, W., & Zhang, W. (2016). Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish. Journal of genetics and genomics = Yi chuan xue bao, 43(10), 593–600. https://doi.org/10.1016/j.jgg.2016.09.001

Xu, J., Wang, T., Wu, Y., Jin, W., & Wen, Z. (2016). Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine. Developmental cell, 38(2), 214–222. https://doi.org/10.1016/j.devcel.2016.06.018

Jin, H., Huang, Z., Chi, Y., Wu, M., Zhou, R., Zhao, L., Xu, J., Zhen, F., Lan, Y., Li, L., Zhang, W., Wen, Z., & Zhang, Y. (2016). c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish. Blood, 128(3), 415–426. https://doi.org/10.1182/blood-2015-12-686147

Wei, Y., Xu, J., Zhang, W., Wen, Z., & Liu, F. (2016). RNA polymerase III component Rpc9 regulates hematopoietic stem and progenitor cell maintenance in zebrafish. Development (Cambridge, England), 143(12), 2103–2110. https://doi.org/10.1242/dev.126797

2011 ~ 2015 (19)

Xu J, Zhu L, He SC, Wu Y, Jin W, Yu T, Qu JY, and Wen ZL. (2015) Temporal-spatial resolution fate mapping reveals distinct origins for embryonic and adult microglia in zebrafish. Developmental Cell 34:632–641.

Shi XG, He BL, Ma CH, Guo YH, Man CH, Ekker SC, Zhang WQ, Zhang YY, Wen ZL, and Leung YH. (2015) Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish. Blood 125:2974-2984

Yuan H, Zhang T, Liu X, Deng M, Zhang W, Wen ZL, Chen S, Chen Z, de The H, Zhou J, and Zhu J. (2015) Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish. Scientific Reports 5:9011

Zeng Y, Yan B, Xu J, Sun QQ, He SC, Jiang J, Wen ZL, and Qu JY. (2014) In vivo nonlinear optical imaging of immune responses: tissue injury and infection. Biophysical Journal 107: 2436-2443.

Yan B, Han PD, Pan LF, Lu W, Xiong JW, Zhang MJ, Zhang WQ, Li L, and Wen ZL. (2014) Il-1β and reactive oxygen species differentially regulate neutrophil directional migration and Basal random motility in a zebrafish injury-induced inflammation model. The Journal of Immunology 192:5998-6008.

2006 ~ 2010 (13)

2001 ~ 2005 (9)

1990 ~ 2000 (19)